What is Azacitidine?

Azacitidine

Our knowledge of medicine keeps progressing with time. It is essential to address health impediments with the right kind of medication. Azacitidine may be used to treat myelodysplastic syndrome, a condition that impacts bone marrow. It may also be used in the treatment of some types of leukemia. Azacitidine plays an essential role in the treatment of cancer patients. Leukaemia is a type of cancer that affects the blood-forming tissues. This type of cancer impedes the body’s functioning to fight infections, which may cause further complications for those who suffer from it. Azacitidine helps to address this issue and sometimes even be cured. Azacitidine is, therefore, an important drug for several patients which makes it important for us to understand more about it. 

Azacitidine injection

An Azacitidine injection may be given to a patient to treat a patient for the health issue that they are facing. Injections have several advantages over other administration methods or ways to take medication, as the medicine is directly injected into the person’s bloodstream. As a result, it circulates the whole body with ease as it travels with the blood and may be absorbed while it does. It reaches all the necessary parts it is supposed to reach and does not have to pass through the person’s stomach. As a result, the medication may also avoid degradation in the stomach. Azacitidine injection may be beneficial for patients who need urgent assistance with their case of cancer. While discussing the benefits of the medication, one may also keep Azacitidine injection side effects in mind, which may cause many problems for patients that take it. 

Azacitidine 100 mg 

Every kind of medication may have a particular type of dosage of the drug or weight by which it is measured. Azacitidine 100 mg may generally be the dosage the medicine is sold at. One may want to purchase the medication so that a suitable medical professional may administer them. In that case, they may generally buy a pack with Azacitidine 100 mg, which will then be put into and given via injection. The medication is usually used for fully grown adults who cannot undergo stem cell transplantation for whatever reason. Before receiving Azacitidine 100 mg, the patient must be aware to inform the doctor if you suffer from issues related to the lung, liver, kidney, or heart. This could change the dose of the medication, the prescription, or the course of treatment for the patient entirely.

Azacitidine side effects 

Azacitidine side effects that one should inform a doctor or health care professional about as quickly as possible are:

  • Allergic reactions, which may be in the form of skin rash, itching or hives, swelling of the face, lips, or tongue
  • Low blood counts – this medication may lead to a fall in white blood cells, red blood cells, and platelets. One may be at increased risk for infections and bleeding.
  • Signs of infection which may involve fever, chills, cough, a sore throat, pain during urination
  • Signs of a fall in the number of platelets or increased bleeding, which may be in the form of unexplained bruising, red spots on the skin, black stools, the blood passing with urine
  • signs of a fall in the number of red blood cells – unusually weak or tired, fainting spells, lightheadedness
  • Symptoms of injuries to the kidney, such as issues related to urination or alteration in urine amount 
  • Symptoms of injury to the liver such as dark yellow or brown urine, feeling or flu-like symptoms; light-colored stools; loss of appetite, feeling nauseous, pain in the right upper belly, feeling lethargic, eyes or skin turning yellow

Side effects that generally do not require medical attention are (report to your doctor or health care professional if they continue or are bothersome):

  • Feeling constipated
  • Having diarrhea
  • Feeling nauseous, 
  • Experience vomiting
  • Feel pain or observe redness at the injection site
  • unusually weak or tired

There may be even more side effects and different ways these side effects could manifest in the patients. Even though medication is supposed to positively affect the patients, it may also cause adverse effects. Azacitidine may also have some negative impact on patients. Azacitidine injection side effects depend on height, weight, age, and health condition, among others, which may influence how the medication reacts when administered to the patient. 

Azacitidine injection price 

It may be necessary for some patients to know about the Azacitidine injection price. Healthcare costs have been steeply rising in the past few years because of healthcare crises like the coronavirus pandemic. Affording healthcare has become a challenge for many people. Cancer treatment may also be rather expensive, so people may find it essential to know about the prices of different medications so that they may be able to estimate their total spending on the same. Azacitidine injection price is an important variable. 

The Azacitidine injection price in India is:

  •  Azadine Azacitidine 100mg Injection, 100 Mg/Vial, for Hospital at Rs 2500/vial 

Azacitidine price or cost may vary in different pharmacies but generally, stay around the same range. One can find out about the Azacitidine price or the cost from any local pharmacy, online pharmacy, or website that may sell the same. One can also find out other general information such as Azacitidine uses, Azacitidine injection side effects, and Azacitidine side effects in the elderly, among others, besides Azacitidine price or Azacitidine cost. Online pharmacies may also have the option to consult a pharmacist from the site. It must, however, be noted that if there is any advice that is more particular to the patient rather than as general that the patient would like to discuss, they shall do the same with their doctor rather than their pharmacist. 

Azacitidine uses 

One may want to know more about Azacitidine’s uses. Different medications may be used for different purposes related to the treatment of patients. Patients may be treated and sometimes even cured of the health impediment that they are facing. There are a handful of Azacitidine uses. Azacitidine may be used in tackling cancer; Chemotherapy is given to patients of certain kinds of cancer, which will use Azacitidine. Azacitidine may also be referred to as Vidaza or Onureg. Azacitidine may be used to treat myelodysplastic syndrome, which is a condition that impacts bone marrow. It may also be used in the treatment of some types of leukemia.

Azacitidine side effects in elderly people

Different kinds of medication may cause different side effects in patients. Elderly people sometimes face different health circumstances than those who are younger than them. This may lead patients or prospective patients to wonder if elderly patients may have to take special precautions when taking medication. They may also want to know about Azacitidine’s side effects in elderly people. Elderly people may face no difference in the efficacy of Azacitidine concerning people who are younger than them. They may therefore be given the same dose as regular patients for their treatment.

Some notable Azacitidine side effects in elderly people are:

1. Renal function 

There may be regular assessments of patients done. These assessments may ensure that the kidneys remove the drug and its metabolites. When taking Azacitidine, older people may suffer from a risk of reduced renal functioning.

2. Renal Impairment

Some patients may have elevated serum creatinine and BUN levels due to renal issues. As elderly people are at a greater risk of suffering from renal problems when taking Azacitidine, they may be advised to delay the next treatment cycle until elevated values return to normal. They may also be recommended to initiate a 50% dose reduction in the next course. The subcutaneous administration of Azacitidine may not impact those suffering from severe renal issues and impairment. Therefore, Azacitidine may be given to patients with renal failure without altering the dose per the first cycle. 

3. Hepatic impairment

Patients may experience hepatotoxicity on taking Azacitidine, especially if they have experienced liver failure. One may take caution when taking Azacitidine in such a situation.

What conditions should a person inform their doctor about before taking the medication?

A doctor may need to be informed of any of the following conditions of the patient who is going to be taking Azacitidine:

  1. Have a kidney disease
  2. Are you suffering from liver disease
  3. Have a tumor or tumors in the liver 
  4. Have you had any reaction to Azacitidine, mannitol, other medicines, foods, dyes, or preservatives
  5. Are you currently pregnant or trying to get pregnant
  6. Are nursing a child (breastfeeding)

How should a person take Azacitidine?

The patients themselves may take some medication from time to time. Medical staff may administer some kinds of medicine to patients, such as doctors, nurses, etc., at a hospital or suitable medical facility. Azacitidine is also given to a patient by doctors or other medical staff via injection. Patients must n oy administer Azacitidine to themselves. They must make the necessary appointment and take the injection, which supplies the medication into their bloodstream. 

Self-care tips for people taking Azacitidine

Patients may need to care for themselves in a particular way when they take a specific medication. They may also have to do some self-care when they are taking Azacitidine. 

Self-care tips that a patient should take while being given Azacitidine are: 

  1. One must try to drink water regularly unless they have been instructed differently
  2. A patient taking the medication may be at risk of infection. They must avoid crowded places, people with colds, illnesses, etc. The patient must report fever or any signs of infection to their doctor immediately
  3. Keep hands clean
  4. Try to avoid bleeding by using an electric razor or toothbrush that has soft bristles 
  5. Contact sports or activities that may injure a person should be avoided
  6. To reduce nausea, take anti-nausea medications as your doctor prescribes, and eat small, frequent meals.
  7. Alcoholic drinks should be consumed in small amounts or be avoided altogether; the patient may consult their doctor about what amount of alcohol would be okay for them
  8. Get a lot of rest
  9. Consume nutritious food 
  10. Stay as active as possible, even if this only involves gentle exercise 
  11. In case of any side effects, a patient must take the responsibility to discuss them with their doctor or medical team 

What is the brand name of Azacitidine?

It may be a good idea to be familiar with the different medication names to avoid confusion during treatment while purchasing medication or consulting some medical authority about one’s treatment. The brand name of Azacitidine is Vidaza.

Monitoring and testing of patients who are given Azacitidine

Patients who are given Azacitidine medication may be monitored and tested for a period after taking the injection for the same. This will ensure that no side effects are occurring and that the therapy being given to the patient is working as intended. 

What if I miss a dose of Azacitidine?

Patients must try and attend all their appointments where they will be given the Azacitidine medication. In case they miss an appointment or are unable to participate in it, they must consult the doctor that they are visiting for their treatment as to what they must do. 

What if I overdose on Azacitidine?

Azacitidine is given to a patient by trained medical staff. They are usually well-trained and give injections to other patient ends regularly. However, human error may occur at times, leading to an overdose of Azacitidine medication. The patient must be observed for many overdose symptoms in such a situation. They may have a severe reaction, in which case the patient may be taken to the facility’s emergency room. One may have to call a poison control hotline, the employees of which may be able to tackle the issue properly. 

Where should Azacitidine be stored?

One may want to know where or how medication may be stored. Azacitidine should be stored at a medical facility and not at home. It may also only be administered to the patient by medical staff. A patient must contact their doctor, pharmacist, or healthcare provider if they want to know more about this.

How does the medication work?

A harmful or malignant tumor causes cancer. Two kinds of tumors may be found in the body of a person. One is benign, and the other is a malignant tumor. The benign tumor does not spread and invade other cells, tissues, and organs. Malignant tumors spread rapidly and cause harm to the cells, tissues, and orangs that they may be located on or near. The malignant tumor may slow down the functioning of the organs and other parts of the body poof the person, causing the person to be unable to care for themselves or function suitably. Sometimes the cancerous or malignant tumor may cease so much function in the body, which may even result in the person’s death. 

Azacitidine may be given to a patient when a doctor feels it is necessary. Azacitidine interferes with the growth of genetic material, DNA, and RNA of cancerous cells in a leukemia patient. The growth of the cancer cells is inhibited as doses of Azacitidine are given to the patient, and the best-case scenario is the complete disappearance of the malignant tumor. Normal maturation and growth of young blood cells in the bone marrow may occur in the person’s body. 

Safety advice related to Azacitidine

A patient must take some safety precautions if given Azacitidine for a smooth treatment:

1.Alcohol

Alcohol should be taken with caution when taking Azacitidine injections. Medications may often react with alcohol, causing some unpleasant side effects. The patient must therefore try and consult their doctor before any alcohol consumption while taking medication to ensure what amount may be suitable and what precautions they may want to take beforehand.

2.Pregnancy 

Pregnant women may usually be advised not to take Azacitidine as it could cause harm to the fetus and impede fetal development. In some situations where the benefits outweigh the risks and the person faces a life-or-death crisis, a doctor may allow the pregnant woman to take Azacitidine. One must consult a doctor if they are pregnant and may face a health issue where Azacitidine may be used for treatment. 

3.Breastfeeding 

If a woman is taking Azacitidine and breastfeeding simultaneously, this could be toxic for the baby as the medication may be passed through the breast milk of the woman. It is resultantly not usually recommended to have Azacitidine while breastfeeding or nursing. 

4.Driving 

A person must try and avoid drinking when taking Azacitidine. Azacitidine may cause drowsiness and tiredness, which could hamper the safety of the patient as well as others who may be driving on the road. It could lead to road accidents as a result of disoriented driving. 

5.Kidney disease

One must inform their doctor or medical authority if they suffer from kidney disease. If a person is suffering from some issue related to their kidneys, this patient’s health condition may lead to a change in the medication or a change in dosage given to the patient. 

6.Liver 

Azacitidine medication must not be given to patients who have liver cancer. Patients suffering from liver disease may need a change of dosage amount of Azacitidine. One must inform their doctor if they are suffering from liver-related issues.

Contraception

Adults taking Azacitidine may be advised to take a suitable form of contraception. Both men and women who may be able to bear children must use proper contraceptive methods to prevent pregnancy while being given Azacitidine. Men may want to get some advice on sperm preservation before being given Azacitidine treatment. If one wants to know more about taking Azacitidine and using the right kind of contraception, one may consult their doctor or a suitable medical professional. They may be able to give more advice based on a greater amount of personal information that may be provided to them by the patient.

How to manage Azacitidine side effects

One may experience Azacitidine side effects. The reactions may cause discomfort or inconvenience for a person. They may want to know how to deal with the same.

A patient may handle Azacitidine side effects in the following way:

1. Mouth Ulcers 

A patient may get mouth ulcers as a reaction to Azacitidine. Patients must avoid eating spicy food and stay well-hydrated to deal with these mouth ulcers. One may use gels that may soothe the pain of ulcers, too, to help with the pain. If the situation does not improve over time or on using any of these methods, the patient may approach a doctor or necessary medical authority to help with the same.

2. Constipation  

When taking Azacitidine, a patient may experience constipation. The patient must eat fiber-rich food to deal with constipation caused by Azacitidine injection. This food may include fresh fruits, vegetables, and cereals; They must stay adequately hydrated. Regular exercise may also help with constipation. If none of the above help, a doctor may suggest alternative treatments for constipation.

3. Injection site reactions 

One may observe some reactions on the site at which the injection of Azacitidine was. In such a situation, the person may place an ice pack on the place where the injection had been given. If the reaction on the injection site becomes too severe, one must contact a suitable medical authority or doctor. 

Conclusion 

Medication is one of the most important parts of any treatment. A doctor, patient,  medical staff, medical facilities and medication are all the elements that come together to treat or cure a patient. It is a good idea to try and understand a medical procedure one is going through, even if one is not a trained medical professional. A patient must know about the kind of medication they are taking, its side effects, price, uses, etc. This will allow them to have a smoother treatment and receive the best care possible from their doctor and medical staff that is overlooking their treatment. An aware patient may know what to inform their doctor about, what aspects of the medication are important and applicable to them, etc. Azacitidine assists a handful of patients suffering from health issues that may need a specific procedure, especially cancer patients. It is an important medication that may not only change a person’s life with the right use but may also save it. 

It is also essential to note that Azacitidine’s price along with the expenses incurred throughout cancer treatment can be a significant concern for many patients. The high cost of cancer treatments in general, including chemotherapy drugs, can place a financial burden on individuals and their families. In such cases, crowdfunding can be a great tool to help alleviate the cost of cancer treatment.